Effect of nutgrass galingale rhizome decotion on contractile activity of uterine smooth muscle strips of non-pregnant rats in vitro
- VernacularTitle:香附对未孕大鼠离体子宫肌收缩的影响
- Author:
Zhiqiang LI
;
Liyang MA
;
Jingdong XU
;
Huixia YANG
- Publication Type:Journal Article
- Keywords:
rat;
isolate uterine smooth muscle;
nutgrass galingale rhizome;
diphenhydramine;
phentolamine;
verapamil;
indomethacin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of nutgrass galingale rhizome decotion on contractile activity of uterine smooth muscle strips of non-pregnant rats.Methods We selected 60 Wistar non-pregnant rats of weight 250-300 g to record the effects of nutgrass galingale rhizome decotion(1.0 g/L,2.0 g/L,4.0 g/L,8.0 g/L) on contractile activity of uterine smooth muscle strips of non-pregnant rats with Biolap 410 Biological System.Four antagonists,diphenhydramine(2?10-6mol/L),phentolamine(2?10-6mol/L), verapamil(2?10-7mol/L),and indomethacin(2?10-5mol/L) were used to study their mechanisms respectively.Results Water extract of nutgrass galingale rhizome(4?10-3kg/L) could significantly weaken uterine contractile activity of non-pregnant rats,lessen the frequencies,shorten the duration and lower the amplitude of contractile activity.Conclusion The effect of nutgrass galingale rhizome on contractile activity of uterine smooth muscle strips in rats may be mainly associated with prostaglandin synthese or release nothing with L-voltage-dependant calcium channels,H1 receptor or ? receptor.
