The correlation and clinical significance of interleukin-6 and myeloid cell leukelia-1 expression in human cervical cancer
- VernacularTitle:人类宫颈癌中白细胞介素-6与髓样细胞白血病-1表达的相关性及临床意义
- Author:
Yao MA
;
Jing WU
;
Xiumin ZHAO
- Publication Type:Journal Article
- Keywords:
interleukin-6;
myeloid cell leukelia-1;
cervical cancer;
apoptosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and correlation of interleukin-6(IL-6),myeloid cell leukelia-1(MCL-1) protein and MCL-1mRNA in cervical cancer,cervical intraepithelial neoplasia(CIN) and normal cervix.Methods Immunohistochemistry was used to detect the expression of IL-6 and MCL-1 protein in 30 samples of cervical squamous cell carcinoma,10 samples of CIN and 10 samples of normal cervix,and RT-PCR was used to detect the expression of MCL-1mRNA.Results The protein levels of IL-6 and MCL-1 were significantly higher in cervical cancer tissues than in normal cervix and CIN tissues(P
