Effects on TGF-?1 and T?RⅠ in Carcinogenesis and Prognosis of Gallbladder Carcinomas
- VernacularTitle:TGF-?1和T?RⅠ在胆囊癌发病及预后中的作用
- Author:
Yaqing ZHU
;
Shuzhou CHEN
;
Yuquan CHEN
;
Xuehao WANG
- Publication Type:Journal Article
- Keywords:
Gallbladder carcinoma Transforming growth factor ?1 Transforming growth factor receptor type Ⅰ Carcinogenesis Prognosis
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between expressions of transforming growth factor ?1 (TGF-?1), transforming growth factor receptor type Ⅰ (T?RⅠ) and cell proliferation, cell cycle in gallbladder carcinomas, to disclose the mechanism of TGF-?1 and T?RⅠin the gallbladder carcinogenesis,and to evaluate their values in the prognosis of gallbladder carcinomas. Methods Thirty five gallbladder carcinomas age (57.94? 4.61) years, 14 male cases and 21 female cases comprised 32 adenocarcinomas, 2 adenosquamous carcinoma and 1 squamous cell carcinomas. Formalin fixed, paraffin embedded sections from gallbladder carcinomas were immunostained with TGF-?1, T?RⅠ, PCNA, cyclin E antibodies by immunochemical assays. Gallbladder adenoma and chronic cholecystitis were collected as non-malignant controls. Patients of gallbladder carcinomas were followed up. Results Positive immunostaining rate of TGF-?1 was 57.14% in gallbladder carcinomas, which was significantly higher than that in gallbladder adenomas and chronic cholecystitis (P
