Influence of Cigarette Smoke Free Radical on Blood Biochemical Parameters,Lung and Cell Micronucleus Rate in Rats
- VernacularTitle:香烟烟气自由基对大鼠血液生化指标和肺及红细胞微核的影响
- Author:
Shaochun MAO
;
Zhuying LI
;
Cong LI
- Publication Type:Journal Article
- Keywords:
Tobacco smoke pollution;
Free radicals;
Blood biochemical parameter;
Micronucleus tests;
Respiratory system
- From:
Journal of Environment and Health
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of the low free radical cigarettes (test cigarettes) on the blood biochemical parameters,lung and polychromatophilic red cell micronucleus in rats. Methods 36 SD rats were randomly divided into the blank control group,the comparison smoke group and the experimental smoke group (low free radical cigarettes),12 in each. Let the rats smoke passively for 30 day,daily 12 cigarettes,then the determination of blood biochemical parameters and the polychromatophilic red cell micronucleus rate in the bone marrow,the pathological examination of the trachea and the lung tissues were conducted. Results Compared with the blank control,no significant changes were seen in the blood biochemical parameters and the polychromatophilic red cell micronucleus rate. The pathological examination of the lung tissues indicated that the pathological changes in the experimental smoke group were slight compared with the comparison smoke group. Conclusion No seriously adverse effects of low free radical cigarettes on the lung tissues of rats have been seen in the present study,that indicates that maybe the low free radical cigarette has an advantage in the health safety.
