The Value of Three-Dimensional Proton MR Spectroscopic Imaging in the Differential Diagnosis of Prostate Cancer in Peripheral Zone
- VernacularTitle:3D~1HMRSI对外周带前列腺癌的鉴别诊断价值
- Author:
Ximing WANG
;
Renju BAI
;
Liang GUO
;
Xin ZHAO
- Publication Type:Journal Article
- Keywords:
benign prostatic hyperplasia;
prostate cancer;
MRI;
three-dimensional proton MR spectroscopic imaging (3D 1HMRSI)
- From:
Journal of Practical Radiology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the metabolic characteristic of prostate cancer(PCa) in peripheral zone (PZ) with three-dimensional proton MR spectroscopic imaging (3D MRSI),and to evaluate the value of 3D MRSI in the differential diagnosis of prostate cancer in PZ. Methods 3D MRSI findings were reviewed in 18 benign prostatic hyperplasia (BPH) cases and 21 PCa cases.(Cho+Cre)/Cit and Cho/Cre ratios of PCa and PZ of BPH were retrospectively measured,(Cho+Cre)/Cit and Cho/Cre of PCa voxels were compared with BPH voxels. Results PZ of BPH showed dominant Cit,which was markedly higher than Cho and Cre. Significantly higher choline levels and lower citrate levels were observed in PCa compared with that of BPH. It showed statistically significant difference between (Cho+Cre)/Cit ratios of PCa voxels and BPH voxels,PCa voxels had minimal overlap with BPH voxels. It also showed statistically significant differences between Cho/Cre ratio of PCa voxels and BPH voxels,but there was some overlap between two groups. Conclusion 3D MRSI can be successfully applied to the diagnosis of cancer in the PZ on the basis of the elevation of Cho and the reduction Cit in cancerous tissue compared with that of PZ tissue of BPH.
