Study on intervention of the acute inflammatory responses following myocardial infarction by diltiazem
- VernacularTitle:地尔硫卓对急性心肌梗死后大鼠心肌炎症的干预研究
- Author:
Ying LIU
;
Yuhua LIAO
;
Xiang CHENG
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Ventricular remodeling;
Diltiazem;
Cytokine
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of diltiazem on ventricular remodeling and inflammation in rat heart following acute myocardial infarction(AMI).Methods:The model of AMI rats was randomly divided into diltiazem group(D group)and control group(AMI group),besides another group of sham operation(S group).The data of ejection fraction(EF) and the left ventricular mass(LVM)were examined with echocardiography,and leukocyte infiltration in situ was analyzed on the HE staining slices,with the expression of proinflammatory cytokines(IL-I?,IL-6,TNF-?)detected by RT-PCR at 1d,3d,1w,2w and 4w intervals after AMI.Results:The results from echocardiography showed that EF increased(73.7?3.1% vs 61.0?2.6%)and LVM decreased(0.81?0.12g vs 0.92?0.12g),both significantly in D group at 4w,compared with those of the AMI group(P
