An in vivo study of the inhibitory effect of erythromycin on wear particles induced osteolysis
- VernacularTitle:红霉素抑制磨损颗粒诱发体内骨溶解的研究
- Author:
Chao ZHANG
;
Kerong DAI
;
Tingting TANG
- Publication Type:Journal Article
- Keywords:
wear particles;
aseptic loosening;
osteolysis;
erythromycin
- From:
Orthopedic Journal of China
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]In present study an in vivo wear particles induced mouse calvarial osteolysis model was used to investigate the inhibitory effect of erythromycin over wear particles induced osteolysis.[Method]Twenty-four male eight-week-old C57BL/J6 mice were allocated into 4 groups: PMMA group receiving 30 mg PMMA particles implantation onto the calvariae,PMMA+2EM group receiving 30 mg PMMA particles implantation and EM 2mg/kg ip injection,PMMA+10EM group receiving 30 mg PMMA particles implantation and EM 10mg/kg ip injection,control group receiving sham operation.Seven days later,mice calvariae were harvested for pathology analysis.[Result]Middle suture area in the control group was 0.079 mm2?0.011 mm2,in PMMA group 0.335 mm2?0.129 mm2.In PMMA+2EM group the area was 0.094 mm2?0.019 mm2,PMMA+10EM group was 0.091 mm2?0.028 mm2.Osteoclasts number in osteolysis area in the control group were 5.3?1.0,in PMMA group 19.2?5.3,PMMA+2EM group was 6.6?1.1,PMMA+10EM group 6.1?1.9.Compared with control group,PMMA particles induced significant osteolysis(P
