Toxic Effects of Rotenone on Substantia Nigra of Rats
- VernacularTitle:鱼藤酮对大鼠中脑黑质组织的毒性
- Author:
Yan SAI
;
Qiang WU
;
Zhaojun DONG
- Publication Type:Journal Article
- Keywords:
Rotenone;
Substantia nigra;
Oxidative stress;
Toxic effect
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the toxic effects of rotenone on substantia nigra of rats. Methods Rotenone was given subcutaneously once a day during 28 days. Substantia nigra was dissected. Morphology of dopamine neuron, synapse and myelin sheath were observed. SOD and GSH-Px activity were assayed; MDA and GSH contents were measured. Results Autonomic activities of rats decreased, similar to Parkinson's Symptoms. Morphology of dopamine neuron changed, synapse structures were abnormal, synapse vesicals increased and myelin sheath degenerated. MDA content increased (P
