Systems Toxicology:a New Orientation of Toxicological Research
- VernacularTitle:毒理学发展的新方向——系统毒理学
- Author:
Xianliang WANG
;
Yunjiang YU
;
Hongmei WANG
- Publication Type:Journal Article
- Keywords:
Systems toxicology;
Transcriptomics;
Proteomics;
Metabonomics;
Toxicogenomics
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
With the development of systems biology and high-throughput molecular technologies, systems toxicology has come into being. The up-date understanding of systems toxicology is the study of the perturbation of biological systems by using chemicals and stressors, monitoring changes in molecular expression (transcript, protein and metabolite profiling), conventional toxicological parameters and iteratively integrating response data to describe the functioning organism. The background, research framework, supporting tools and the main applications of systems toxicology were discussed in detail in the present paper. Although in its infancy, systems toxicology will play an important role in advancing the study of environmental stress and heath impact definitely.
