A case of levocetirizine-induced liver injury.
- Author:
Moon Chan JUNG
1
;
Ja Kyung KIM
;
Jae Yeon CHO
;
Jae Won SONG
;
Bohyun LEE
;
Ji Won PARK
;
Jinwon SEO
;
Sung Eun KIM
Author Information
- Publication Type:Case Reports
- Keywords: Hepatotoxicity; Levocetirizine; Cholestasis
- MeSH: Cetirizine/*adverse effects/therapeutic use; Chemical and Drug Induced Liver Injury/*diagnosis/pathology; Histamine H1 Antagonists, Non-Sedating/*adverse effects/therapeutic use; Humans; Hypersensitivity/drug therapy; Jaundice/etiology; Liver/pathology; Male; Middle Aged; Pruritus/etiology
- From:Clinical and Molecular Hepatology 2016;22(4):495-498
- CountryRepublic of Korea
- Language:English
- Abstract: Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. A 48-year-old man was hospitalized with jaundice and generalized pruritus that had developed after 2 months of therapy with levocetirizine for prurigo nodularis. Laboratory findings revealed acute hepatitis with cholestasis. A liver biopsy demonstrated portal inflammation and hepatitis with apoptotic hepatocytes. The patient fully recovered 3 weeks after withdrawing levocetirizine. Although levocetirizine is safe and effective, physicians should be aware of its potential hepatotoxicity.
