The influence of chronic neuropathic pain on cellular immune function of mice
- VernacularTitle:慢性神经病理性痛对小鼠细胞免疫功能的影响
- Author:
Lingqiao SHAO
;
Yukang YUAN
;
Junyang WANG
;
Huixun REN
- Publication Type:Journal Article
- Keywords:
chronic neuropathic pain;
tumor necrosis factor-?;
interleukin-6;
T lymphocyte
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of chronic neuropathic pain on cellular immune function of mice models.Methods The mice models were established by ligating tibeal nerve and common peroneal nerve on one side,and the influence of chronic neuropathic pain on cellular immune function and tumor necrosis factor-?(TNF-?) and interleukin-6(IL-6) was observed with lymphocyte cell increase experiment(MTT method) and enzyme linked immunosorbent assay(ELISA).Results The increased reactivity of T lymphocyte of the model group was significantly higher than that of the sham group and the control group.At the same time,content of TNF-? and IL-6 in blood of the model group also increased.Conclusion Cellular immune function of mice is increased in the state of chronic neuropathic pain.
