Tridimensional metrological analysis of Baogan Jiedu Granule on liver cell ultrastructure of model mice with acute liver injury induced by tetracycline
- VernacularTitle:保肝解毒颗粒对四环素致急性肝损伤小鼠肝细胞超微结构的立体计量学分析
- Author:
Baoping LU
;
Jianguo LI
;
Xiaona YANG
- Publication Type:Journal Article
- Keywords:
Baogan Jiedu Granule;
acute liver injury;
animal model;
tetracycline;
cell ultrastructure;
three-dimensional metrological analysis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Baogan Jiedu Granule on liver cell ultrastructure of model mice with acute liver injury induced by tetracycline.Methods Totally 60 mice were randomly divided into tetracycline model group,large-dosage,medium-dosage and small-dosage groups of Baogan Jiedu Granule,Ganlixin group and control group.Each group was respectively perfused with corresponding drug for 5 days and tetracycline was perfused once to make the model.The tissues were observed by electron microscope,and the liver cell ultrastructure was measured and analyzed by three-dimensional metrology.Results The amount of mitochondria Vv,heterochromatin Vv,mitochondria ?m,endoplasmic reticulum ?m and Golgi's apparatus ?m all obviously decreased in model group,while that of euchromatin Vv and lipid droplet Vv increased.Baogan Jiedu Granule could remarkably increase the amount of indexes referred above,and decrease the amount of euchromatin Vv and lipid droplet Vv.Conclusion Baogan Jiedu Granule can significantly ameliorate the pathologic change of liver cell ultrastructure,thus having a good hepatoprotective effect.
