Cellular immune mechanism of anti-tumor efficacy of Shenqi injection in H22 tumor-bearing mice
- VernacularTitle:参芪注射液对H22荷瘤小鼠抑瘤作用的细胞免疫机制
- Author:
Long MEI
;
Xiaohui DONG
;
Gang DUAN
;
Wei GOU
- Publication Type:Journal Article
- Keywords:
tumor bearing mouse;
Shenqi injection(SQI);
inhibitory rate(IR);
interleukin-2(IL-2);
interferon-?(IFN-?);
cellular immune function
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between in vivo anti-tumor efficacy of Shenqi injection and its effect on immunologic function in H22 tumor-bearing model mice,and explore the cellular immunologic mechanism of Shenqi injection in inhibiting tumor growth.Methods Three different doses of Shenqi injection were given to H22 tumor-bearing model mice in treatment groups.The tumor growth inhibitory rate(IR) and the index of phagocytosis of peritoneal macrophage were calculated.MTT assay was used to observe the effect of Shenqi injection on spleen lymphocytes stimulated by ConA in vitro separated from H22 tumor-bearing mice.Murine serum IL-2 and IFN-? were detected by means of ELISA assay.Results IR was significantly reduced in two treatment groups compared with that of the model mice(60.72%,48.65%,P
