Rivalry mechanism of ginkgo in rat brain edema after intracerebral hemorrhage
- VernacularTitle:金纳多对抗大鼠脑出血后脑水肿的作用机制
- Author:
Xiaopeng YANG
;
Qiufang LI
;
Ruiling YANG
- Publication Type:Journal Article
- Keywords:
ginkgo;
cerebral hemorrhage;
brain edema;
superoxide dismutase;
malondialdehyde;
hemeoxygenase-1
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the rivalry mechanism of ginkgo in rat brain edema after intracerebral hemorrhage.Methods Totally 80 healthy Wistar rats were divided into 4 groups randomly(20 rats in each group).Fifty microliters saline(group A and group B) or auto-hemoglobin(group C and group D) was infused into the right caudate nuclears using stereo tactic guidance.Groups A and C were lavaged 50 g/L carboxymethyl cellulose sodium solution of 3 mL,groups B and D were lavaged the same amount of ginkgo(200 mg/kg) solution dissolved by 50 g/L carboxymethyl cellulose sodium solution once a day for 3 weeks.All the rats were decapitated after raised for 3 weeks,and superoxide dismutase,malondialdehyde,and the number of hemeoxygenase-1(HO-1) positive cells in brains were assayed.Results The differences in SOD and MDA contents as well as HO-1 positive cell number between every two groups were significant(P
