Expression of TNF-?,MMP-9 and TIMP-1 in the lesions of psoriasis vulgaris
- VernacularTitle:寻常型银屑病皮损中肿瘤坏死因子-?、基质金属蛋白酶9及其抑制剂-1的表达
- Author:
Wanjuan WANG
;
Li CHEN
;
Xiaopeng WANG
;
Hongmin LI
;
Yingjuan WANG
;
Xiuying WANG
- Publication Type:Journal Article
- Keywords:
psoriasis;
tumor necrosis factor-?(TNF-?);
matrix metalloproteinase-9(MMP-9);
matrix metallo-proteinase inhibitor-1(TIMP-1)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of TNF-?,MMP-9 and TIMP-1 in the lesions of psoriasis vulgaris.Methods SABC immunohistochemical technique was used to examine the expression of TNF-?,MMP-9 and TIMP-1 in lesional skin of 40 cases and uninvolved skin of 20 cases of psoriasis and in skin of 20 cases normal controls.Results The expression of TNF-? and MMP-9 was significantly higher in the lesional skin than that in nonlesional skin and normal controls(P0.05).There was a positive correlation between the expression of TNF-? and MMP-9(r=0.471,P
