Suppressing Function of Breast Cancer Metastasis Suppressor 1 in Breast Cancer Metastasis
- VernacularTitle:乳腺癌转移抑制基因1抑制乳腺癌转移的作用机理研究进展
- Author:
Jing XIE
;
Jun JIANG
- Publication Type:Journal Article
- Keywords:
Breast cancer metastasis suppressor 1 Breast cancer Metastasis
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the recent studies on the suppressing function of breast cancer metastasis suppressor 1 (BRMS1) in breast cancer metastasis. Methods The recent literatures on the mechanisms of BRMS1 in the breast cancer that were published in and abroad were reviewed and summarized. Results BRMS1, similar to the other anti-metastasis genes, only suppresses the metastasis of breast cancer cells but has nothing to do with the growth of tumor. BRMS1 could suppress metastasis of tumor cells by reestablishing both the homospecific and the heterospecific gap junctional intercellular comminications (GJIC) and by altering the expressions of relevant metastasis genes in the breast cancer. Conclusion Further studies on BRMS1 may be helpful to understand the metastasis of breast cancer, which may provide a new way for the diagnosis and treatment of breast cancer.
