Effects of Perinatal Exposure to Bisphenol A on Expression of ER mRNA in Cerebral Tissue of Weaned Male Offspring of Rats
- VernacularTitle:围生期母鼠双酚A暴露对断乳期雄性子代大鼠脑组织中雌激素受体mRNA表达的影响
- Author:
Dongmei LONG
;
Weibo CHENG
;
Hao ZHANG
- Publication Type:Journal Article
- Keywords:
Environmental endocrine disruptors;
Estrogen receptor;
Brain;
Bisphenol A
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of perinatal exposure to bisphenol A(BPA) on the expression of estrogen receptor ? and ? mRNA in the brain of F1 male offsprings. Methods Pregnant SD rats were given BPA at 2, 20, 100 mg/kg bw per day respectively from eleventh day of gestation throughout the whole lactation by gastric gavage until their pups were weaned on postnatal day 21, F1 male pups from each group were killed on postnatal day 21 respectively, the brain was removed for detecting the expression of estrogen receptor ? and ? mRNA by RT-PCR. Results BPA treatment caused a up-regulation of ER? mRNA and ER? mRNA relative expression in the brain,especially in the middle-dose and low-dose groups it was so obvious. Conclusion Perinatal exposure to BPA can cause a change of ER? mRNA and ER? mRNA expression in the brain of the male offspring,which may be a part of the mechanism of BPA induced brain development damage.
