Effect of Vanadium on Antioxidase Activity in Liver Microsome and Mitochondrion of Rats
- VernacularTitle:钒对大鼠肝线粒体微粒体抗氧化酶活力的影响
- Author:
Suling SUN
;
Jian ZHOU
;
Hebang CHEN
- Publication Type:Journal Article
- Keywords:
Vanadium;
Glutathione peroxidase;
Catalase;
Superoxide dismutase;
Malondialdehyde
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of vanadium on antioxidase activity in liver microsome and mitochondrion of rats. Methods 40 Wistar rats were randomly divided into 7 groups, 6 experimental groups, 1 control group. The rats in experimental groups were treated with ammonium metavanadate through drinking water at the doses of 1.25, 2.5, 5, 10, 20 and 40 mg/kg respectively for 20 consecutive days. The rats in control group were treated with distilled water. GSH-Px, CAT activity in liver microsome and SOD activity, MDA content in liver mitochondrion were determined. Results GSH-Px, CAT, SOD activity decreased and MDA content increased as ammonium metavanadate dosage increased. Compared with the control group, GSH-Px and CAT activity in 5, 10, 20 and 40 mg/kg groups decreased significantly(P
