Determination of Safrole and 6-methyl Coumarin in Cosmetics Using GC and GC-MS
- VernacularTitle:化妆品中黄樟素和6-甲基香豆素的气相色谱-质谱测定法
- Author:
Xing WANG
;
Tianpei CAI
;
Chao WANG
- Publication Type:Journal Article
- Keywords:
Cosmetic;
Gas chromatograephy-mass spectrometry;
Safrole;
6-methyl coumarin
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a method for separation and determination of safrole and 6-methyl coumarin in cosmetics by GC-MS. Methods The cosmetics were extracted with methanol and then dehydrated,and filtrated through the membrane of 0.45 ?m. The filtration liquid was injected into GC and GC-MS for detection and quantitative analysis with external standard method. Results The recovery rates of safrole and 6-methyl coumarin were 101.3%-106.0% and relative standard deviations of safrole and 6-methyl coumarin were 0.9%-1.4% and 0.9%-2.1% respectively. The detection limits were 5 and 10 ?g/g. Conclusion This method is accurate and sensitive for detection of safrole and 6-methyl coumarin in cosmetic.
