The function of caveolins in neoplasia and its progressing
- VernacularTitle:凹陷蛋白在肿瘤发生发展中的作用
- Author:
Miaomiao ZHANG
;
Kangda LIU
- Publication Type:Journal Article
- Keywords:
caveolin;
caveolae;
cancer
- From:
China Oncology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Caveolin,a membrane protein of 21-24 k,is the main structural component of caveolae,it plays quite a diverse functional role in maintaining vital activities of cells like endocytosis,cholesterol transport,cell membrane composition,and transduction of transmembrane signal to some virus involved in the processes of virus infection.Caveolin-1 also is a key regulator of multiple steps of oncogenesis and tumor development.Caveolin-1 can also serve as a negative regulator in proliferation,apoptosis,invasion and metastasis in varieties of cancer cells.There are some conflicting roles in different tumors,this review summarized the recent advances in the function of caveolin in cancers.
