Effect of exogenous transforming growth factor-beta 2(TGF-?_2) and bone morphogenetic protein 2(BMP_2) and allografts bone on radius defects healing of experimental rabbits
- VernacularTitle:大段同种异体骨移植复合BMP_2和TGF-?_2对兔桡骨中段骨缺损愈合的影响
- Author:
Liang LIU
;
Dong WANG
- Publication Type:Journal Article
- Keywords:
allografts bone;
transforming growth factor-beta(TGF-?2);
bone morphogenetic protein2(BMP2);
transplant
- From:
Orthopedic Journal of China
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the effect of exogenous TGF-?2and BMP2 and allografts bone on radius defects.[Method]The model of adult rabbit radius defects was made and treated with TGF-?2 and BMP2 respectively or in combination and allografts bone in the radius defects.A group:BMP2 and allografts bone.B group:autogenous bone.C group:TGF-?2 and allografts bone.D group:BMP2 and TGF-?2 and allografts bone.Fracture healing was evaluated in different time by radiograph,biomechanical tests,measurement of the bone mineral density and calcium content in callus.[Result]The results of B group excelledthose of A,C,D group in aspects of calcium content in callus,the ability of radius defects and biomechanical strength of bone(P
