The Study for the Correlation Between the Clinical Results and Neovascularigation and bFGF Expression in Disc Herniation.
- Author:
Chang Hoon JEON
1
;
Han Kyeom KIM
;
Shin Young KHANG
Author Information
1. Department of Orthopaedic Surgery, Ajou University School of Medicine, Korea. chjeon@madang.ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Disc herniation;
Neovascularization;
bFGF
- MeSH:
Fibroblasts;
Intervertebral Disc;
Intervertebral Disc Displacement;
Radiculopathy
- From:Journal of Korean Society of Spine Surgery
2000;7(4):514-520
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
STUDY DESIGN: To study the correlation between the clinical outcomes and neovascularization and bFGF expression in the herniated disc tissues. OBJECTIVES: To study the difference of neovascularization and bFGF expression according to the types of disc herniation, and to study the correlation between the duration of radiculopathy, post-operative results and neovascularization and bFGF expression in the herniated disc tissues. SUMMARY OF LITERATURE REVIEW: Neovascularization has been found in herniated disc tissue. bFGF(basic Fibroblast Growth Factor) in the intervertebral disc has been implicated in the pathogenesis of injury and repair associated with granulation and neovascularization. There is no information on the relationship between clinical outcome and the neovascularization and bFGF expression in the herniated disc tissue. MATERIALS AND METHODS: Among 112 specimens, there are 48 cases in protrusion, 36 in extrusion and 28 in sequestration. Hematoxylin-eosin stain and immunochemical stain with CD 31 and bFGF were used. For the evaluation of post-operative results, Kirkaldy-Willis method was used. The results were analyzed with Chisquare test and t-test. RESULTS: Statistically there is no correlation between the types of disc herniation, duration of radiculopathy and post-operative outcomes and neovascularization and bFGF expression. CONCLUSIONS: The neovascularization and bFGF expression in herniated disc tissue are correlated with the injury of disc tissue. There are no correlation with the clinical outcomes and neovascularization and bFGF expression in herniated disc tissues.
