The effect of L-glutamine on intestinal injury following total hepatic inflow occlusion
- VernacularTitle:谷氨酰胺对肝门阻断后肠道损伤的影响及其意义
- Author:
Guoping LIU
;
Wenxi ZHU
;
Guangshun YANG
;
Wenping ZHOU
- Publication Type:Journal Article
- Keywords:
Glutamine?Ischemia-reperfusion injury?Intestine?Glutathione?Superoxide dismutase
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To explore the effect of L-glutamine(Gln) on intestinal injury following total hepatic inflow occlusion.Methods:Male Wistar rats were assigned randomly to three groups(n=40) :Group A,sham-operation;Group B,control group,rats were pretreated with 4 ml 0.9% saline intraperitonally twice per day on 5 consecutive days;Group C,rats were pretreated with Gln dissolved in 4 ml 0.9% saline intraperitoneally twice per day on 5 consecutive days.The rats in group B and C underwent total hepatic inflow occlusion for 35min by the pringle' s manoeuvre.Ten rats from each group were randomly sacrificed before occlusion and at 2,4,24h after reperfusion respectively.The levels of MDA,SOD,GSH in intestine tissue were measured.The levels of serum TNF-? and portal vein endotoxin were detected.Results:Compared with group A,the levels of GSH and SOD decreased after reperfusion(P
