Investigation for the expressions of Skp2 and P27 in normal and tumor salivary tissues by tissue chip technique
- VernacularTitle:采用组织芯片技术检测正常涎腺及其肿瘤组织中Skp2、P27的表达
- Author:
Lijuan ZHENG
;
Wei WANG
;
Jing LI
- Publication Type:Journal Article
- Keywords:
Tissue chip;
Skp2;
P27;
Salivary gland neoplasms;
Immunohistochemistry
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expressions of Skp2 and P27 in the normal and tumor tissues of salivary glands,and then to evaluate their significance in the development and progression of salivary tumor.Methods:SP immunohistochemical method was used to evaluate the expression of Skp2 and P27 in the normal and tumor tissues of salivary glands. Results:The rates of Skp2 and P27 expression were neither significantly different between polymorphic adenoma and basal cell adenomas, nor significantly different between adenoid cystic carcinoma and mucoepidemoid carcinoma. The rates of Skp2 positive were significantly different between normal salivary glands and benign salivary tumor, as well as between normal salivary glands and malignant salivary tumor. The rates of Skp2 and P27 positive were significantly different between normal salivary glands and malignant salivary tumor.Conclusion:Skp2 overexpression and decreased expression of P27 might play an important role in the development and progression of salivary tumor, overexpression of Skp2 protein may lead to increase of P27 degradation.
