Expression of MMP-9 and its correlation with cancer cell proliferation and metastasis in oral squamous cell carcinoma
- VernacularTitle:基质金属蛋白酶-9在口腔鳞癌中的表达及其与癌细胞增殖和转移的关系
- Author:
Hongjie LI
;
Yuru ZHANG
;
Xiaohong ZHU
- Publication Type:Journal Article
- Keywords:
Oral squamous cell carcinoma;
Matrix metalloproteinase;
Proliferative activity;
Metastasis;
Immunohistochemistry
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of matrix metalloproteinase-9(MMP-9) and its correlation with cancer cell proliferation and metastasis in oral squamous cell carcinoma (OSCC). Methods: Immunohistochemical SP method was used to detect the expression of MMP-9 and Ki-67 in 40 cases of OSCC.Results:The expression of MMP-9 was closely correlated with lymph nodes metastasis and TNM stage of OSCC(P0.05). In cases with lymph nodes metastasis and TNM stage III+IV, the expression of MMP-9 was significantly higher than that in no lymph nodes metastasis and TNM stage I+II(P
