The expression and function of heparanase in the occurrence and evolvement of oral squamous carcinoma
- VernacularTitle:乙酰肝素酶在口腔鳞癌发生发展中的表达和功能
- Author:
Zhong CHEN
;
Hongchao FENG
;
Yufeng SONG
- Publication Type:Journal Article
- Keywords:
Heparanase(Hpa);
Mouth;
Squamous-cell neoplasms;
Angiogenesis
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of Hpa and its correlation with the microvessel density(MVD) in oral squamous-cell carcinoma(OSCC), thereby learning the function of Hpa in the tumor angiogenesis,invasion and lymph node metastasis.Methods:The expression of Hpa was studied in 48 patients with OSCCs, 15 patients with leukoplakia and 10 normal person with healthy oral mucosa by conventional immunohistochemistry and in situ hybridization. MVD was assessed with anti-CD31 antibody. Results: Positive expression ratios of Hpa and Hpa mRNA in leukoplakia were significantly higher than those in normal oral mucosa, while were significantly lower than in OSCC(P
