Expression of integrin ?V?3 in bone remodeling of periodontium during experimental tooth movement
- VernacularTitle:整合素?V?3在实验性牙移动牙周组织骨改建中的表达
- Author:
Xiumei SUN
;
Xinhua SUN
- Publication Type:Journal Article
- Keywords:
Tooth movement;
Bone remodeling;
Integrin ?V?3;
In situ hybridization
- From:
Journal of Practical Stomatology
1996;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the expression of integrin ?V?3 in periodontium during experimental tooth movement, and then to propose the possible role of ?V?3 in bone remodeling during tooth movement. Methods:Thirty-five rabbits were divided into 7 groups (5 rabbits per group):untreated(control), 1,3, 5, 7, 14 and 21 d groups. A elastic coil spring was ligated between the incisors and the first molar and exert a force of approximately 0.78 N to pull the first molar mesially. The animals were sacrificed at each time intervals(1,3,5,7,14 and 21 d) respectively and specimens were made to observe the expression of integrin ?V?3 in periodontium through in situ hybridization. Results:Different extent expression of integrin ?V?3 were seen in osteoclasts, osteoblast precursors, osteoblasts,odontoclasts and odontoblast except bone cells. Conclusions: Integrin ?V?3 may play an important role in bone modeling, cementum resorption and its reparation during experimental tooth movement.
