Joint Effects of Selective Digestive Decontamination and Glutamine on Intestinal Bacterial Translocation of Piggyback Liver Transplantation in Rabbit
- VernacularTitle:选择性消化道去污联合谷氨酰胺预防兔背驮式肝移植肠道细菌易位
- Author:
Li LI
;
Zhu LI
;
Jianghua RAN
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Orthotopic piggyback liver transplantation Intestinal bacterial translocation Selective digestive decontamination Glutamine Postoperative pneumonia
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the joint effects of selective digestive decontamination (SDD) and glutamine (Gln) on preventing intestinal bacterial translocation of orthotopic piggyback liver transplantation and to observe the incidence of postoperative pneumonia in rabbit. Methods Thirty rabbits received orthotopic piggyback liver transplantation and were randomly divided into three groups (SDD group, SDD+Gln group and control group). Mixed emulsion of tobramycin, polymyxin E and nystatin were given to the rabbits in SDD group. Same dosage of the above components plus Gln were given to the rabbits in SDD+Gln group. Samples of portal vein blood, ileum tissue and lung tissue were obtained in each group at different phases during and after operation, the pathological changes of ileum tissue, the bacterial translocation in blood of portal vein and the incidence of postoperative pneumonia were detected. Results The mixing section area of intestinal blood capillaries in SDD+Gln group was smaller compared with control group (P
