CD40L expression on the CD4~+T-cells in children with Kawasaki disease and it’s correlation with coronary artery lesion
- VernacularTitle:小儿川崎病CD4~+T细胞CD40L和E-选择素的表达
- Author:
Yayuan ZHANG
;
Huaying BAO
;
Shengyun SHI
;
Xiaoqing QIAN
;
Juan LI
;
Haiguo YU
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
Intravenous immunoglobulin;
CD40 ligand;
E-selection
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the pathogenesis of coronary artery lesions in Kawasaki disease(KD) by detecting expression of CD40L on T-cells from patients with KD.Methods:Blood samples were collected from 26 patients with KD before and after intravenous immunoglobulin(IVIG) treatment. Age-matched febrile 16 children with various diseases were studied in parallel as controls. Age-matched normal control 15 children were studied as controls. CD40L expression on T-cells was detected by flow cytometry, soluble E-selection and soluble CD40L levels were measured by enzyme-linked immunosorbent assay.Results:CD40L expression on CD4+T-cells and soluble E-selection levels were significantly higher in patients with KD than that in the febrile control(FC) group and normal group(P
