Effects of Volatile Organic Compounds Escaped from Alkyd Dope on Neurotransmitter Content in Brain of Mice
- VernacularTitle:醇酸涂料释放挥发性有机化合物对小鼠脑组织神经递质的影响
- Author:
Zhiyong QIAN
;
Yongmin MA
;
Yongling XIE
- Publication Type:Journal Article
- Keywords:
Air pollution,indoor;
Alkyd dope;
Volatile organic compounds;
Neurotransmitter
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of volatile organic compounds escaped from alkyd dope on neurotransmitter content in the brain of mice.Methods 56 BALB/c mice were randomly divided into 7 groups,8 in each and exposed to volatile organic compounds(30 mg/m3)escaped from alkyd dope by dynamic inhalation exposure.The neurotransmitters(cholines,monoamines,amino acids)in the brain were determined during the period of exposure and comeback.Results Compared with the control,DA,5-HT,NE and Glu significantly decreased and Gly,GABA significantly increased during the period of exposure,however NE still kept significant decrease during the period of comeback.Conclusion Volatile organic compounds escaped from alkyd dope may cause neurochemical change in mice.
