Mutagenecity of Aristolochic Acid to Mouse Lymphoma Cells
- VernacularTitle:马兜铃酸对小鼠淋巴瘤细胞的致突变性
- Author:
Chong WANG
;
Li BAO
;
Hongwei ZHANG
- Publication Type:Journal Article
- Keywords:
Mutagenicity test;
Aristolochic acid;
Genotoxicity
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of the present study was to understand the genotoxicity of aristolochic acid(AA).Methods The mouse lymphoma assay(MLA)was employed to detect the genotoxicity of AA.The cells(L5178Y TK)were treated with AA by adding it into the culture medium at the concentrations of 15,30,60and 120 ?g/ml and then the mutant frequency(MF)was calculated.Results At the dose of 30,60 and 120 ?g/ml,MF increased significantly compared with the control(P
