Effect of prednisolone on LPS-induced RANTES production
- VernacularTitle:泼尼松龙对脂多糖诱导的RANTES的影响
- Author:
Huazi PIAO
;
Chenggao ZHANG
;
Yuhui FANG
- Publication Type:Journal Article
- Keywords:
prodnisolone;
microglia;
RANTES;
lipopolysaccharide
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of prodnisolone on lipopolysaccharide(LPS)-induced RANTES by microglia.Methods The microglia were incubated in MEM culture medium,and different concentrations of LPS 0,100,500,1000?g/L) or LPS(100?g/L) and prodnisolone(10?mol/L) were added into the culture medium.12h later,the amount of RANTES was measured by ELISA.Results Microglia markedly produced RANTES in response to LPS.Prodnisolone significantly reduced the production of RANTES in microglia.Conclusion Prodnisolone has an inhibitive effect on the production of chemokines such as RANTES.
