Changes of ET-1 and TNF-? in dog ARF model during bilateral femoral arteriovenous shunt for extracorporeal membrane oxygenation
- VernacularTitle:无泵驱动体外膜肺转流治疗急性呼吸衰竭犬过程中血浆和肺组织ET-1、TNF-?水平的变化
- Author:
Yang YAN
;
Xigang GENG
- Publication Type:Journal Article
- Keywords:
acute respiratory failure(ARF);
endothelin-1(ET-1);
tumor necrosis factor alpha(TNF?);
extracorporeal membrane oxygenation
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of endothelin-1(ET-1) and tumor necrosis factor alpha(TNF?) in lung homogenate and plasm when acute respiratory failure(ARF) animal models are treated by bilateral femoral arteriovenous extracorporeal membrane oxygenation(bAV-ECMO).Methods Ten ARF dog models were treated by the bAV-ECMO.Right atrium blood and lung tissues were collected at different time points,and ET-1 and TNF? were assayed by radioimmunological method.Results ET-1 content in plasm decreased at first,and at 1h it was elevated and at 2h reached the peak.ET-1 content in lung homogenate reached the peak at 2h and then started to decrease.The analysis of variance showed notable differences(P
