The serum level of leptin before and after rosiglitazone administration in type 2 diabetes
- VernacularTitle:罗格列酮干预前后2型糖尿病患者血清瘦素水平的变化
- Author:
Ye GAO
;
Lan HE
;
Xiaoming WANG
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
leptin;
rosiglitazone;
insulin resistance
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe leptin level before and after rosiglitazone administration and to explore the possible mechanism of rosiglitazone's improving insulin sensitivity.Methods A total of 30 patients newly diagnosed with type 2 diabetes were separated into three groups at random,and treated with rosiglitazone(4mg/d),metform(750mg/d) and gliclazide(160mg/d),respectively.Serum leptin,insulin and GHbA1c were measured after 12 weeks.Results After 12 weeks' treatment,the fasting glucose and GHbA1c in each group declined sharply,while free insulin did not change.The leptin level in rosiglitazone group decreased and insulin sensitivity was improved after administration,but there was no change in metformin and sulfonylureas groups.Conclusion Leptin may play a role in rosiglitazone's mediating the insulin-sensitizing effects.
