Effect of ?,?-carotene in improving H_2O_2 induced damage of osteoblasts
- VernacularTitle:?,?-胡萝卜素改善H_2O_2对成骨细胞损伤的影响
- Author:
Lingpeng PEI
;
Fuhui DONG
;
Bodi HUI
;
Jia ZHU
- Publication Type:Journal Article
- Keywords:
osteoblast;
superoxide dismutase;
membrane fluidity;
?,?-carotene
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ?,?-carotene in enhancing the function of anti-oxidative damage in osteoblasts.Methods M3T3-E1 osteoblasts were randomly divided in five groups: control group,model group,and ?,?-carotene group [low-dose(1?10-8mol/L),medium-dose(1?10-7mol/L),high-dose(1?10-6mol/L)].The activity of cells,superoxide dismutase(SOD),the content of reactive oxygen species(ROS),lipid oxygen(LPO),and membrane fluidity were tested and compared. Results Compared with those in ?,?-carotene groups,the activity of cells,SOD activity and membrane fluidity in the model group were significantly decreased(P
