The Effect of Chronic Intermittent Hypoxia on Cognition and the Expression of Insulin-like Growth Factor-1 in CA1 Region of Hippocampus
- VernacularTitle:慢性间歇性缺氧对认知功能及海马CA1区IGF-1表达的影响
- Author:
Yu YANG
;
Shengyu TAN
- Publication Type:Journal Article
- Keywords:
Chronic intermittent hypoxia;
Cognitive function;
Insulin-like Growth Factor-1
- From:Chinese Journal of Clinical Psychology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of chronic intermittent hypoxia on cognitive functions in Sprague-Dawley rats and the expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus.Methods: Experiments were performed on 16 three-month-old male Sprague-Dawley rats,They were randomly assigned to two experimental groups(n=8/group): chronic intermittent hypoxia group(CIH),and unhandled control group(UC).Rats in UC group were raised normally,and those in CIH group suffered 7H intermittent hypoxia everyday,The duration of experiment was 8 weeks.The learning and memory ability of rats in each group were assessed with the Morris water maze test at the end of the experiments.The expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus was investigated by immunohistochemistry staining and image analysis.Results: ①Morris water maze test learning scores(place navigation): After 5 days training,the escape latency in CIH rats was significantly longer than that in UC rats(P
