Study on the association between DRB1 allele polymorphism and the genetic susceptibility in patients with ulcerative colitis
- VernacularTitle:HLA基因多态性与溃疡性结肠炎遗传易感关系的研究
- Author:
Liying WANG
;
Jiangbin WANG
;
Junling YANG
- Publication Type:Journal Article
- Keywords:
Human leucocyte antigen-DRB1 gene;
Ulcerative colitis;
Genetic susceptibility
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess human leucocyte antigen(HLA)-DRB1 allele polymorphism and analyze the association between DRB1 allele polymorphism and clinical classification of ulcerative colitis.Methods:60 patients were investigated for DRB1 gene by DNA microarray.The results were compared with those from healthy subjects.Results:The frequency of DR2 and DRB1*15 in UC patients were 45% and 41.7% respectively,which were significantly higher than those(23.3% and 21.7%)in controls,the odds ratio being 2.688 and 2.582 respectively(P
