DNA Damage in Bone-Marrow Cells of Mice Exposed to Low Level of Gaseous Benzene
- VernacularTitle:低剂量气态苯暴露对小鼠骨髓细胞DNA的损伤作用
- Author:
Xin SUN
;
Zhuge XI
;
Danfeng YANG
- Publication Type:Journal Article
- Keywords:
Benzene;
Bone-marrow cells;
DNA damage
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the DNA damage in the bone-marrow cells of the mice exposed to the low level of gaseous benzene. Methods 615 mice were divided into 4 groups randomly, 6 in each: the control group, benzene exposed group, group immited by L615K lymphocyte cell, group immited by L615K lymphocyte cell and benzene exposed in combination. Benzene was exposed at the level of 1 mg/m3, 6 h per day for 10 days. SCGE was used to detect the DNA damage in the bone-marrow cells of the mice. Results Compared with the control, the DNA damage were significantly severe in the other 3 groups. But the DNA damage of the group immited by L615K lymphocyte cell and benzene exposed in combination was significantly lower than that of the group immited by L615K lymphocyte cell. The spleen and liver indexes were higher in the two groups immited by L615K lymphocyte cell and immited by L615K lymphocyte cell plus benzene exposed compared with the control group. Conclusion Benzene exposure at the low level can induce the DNA damage in the bone-marrow cells of the mice, but for those lymphatic leukemia mice, benzene exposure at the low level may inhibit this kind of damage, to elucidate the mechanism, further studies needs to be done.
