Observation of ultrapathology in the rat model study of experimental lumbar intervertebral disc degeneration
- VernacularTitle:大鼠退变腰椎间盘组织的超微结构观察
- Author:
Desheng CHEN
;
Qunhua JIN
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
intervertebral disc degeneration;
ultrapathology;
animal model
- From:
Orthopedic Journal of China
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe the change of ultrapathology in the rat model study of experimental lumbar intervertebral disc degeneration.[Method]Thirty-two Sprague-Dawley(SD)rats were divided into two guoups at random,including in the experimental group and the control group.The experimental group was incised through posterior approach along spinous process,resected below erector spinal muscle,the supraspinal and interspinal ligament and the posterior of the zygapophysial joint at the center of the third lumbar spine for providing the rat degeneration of lumbar intervertebral induced by mechanical instability state.The control group was just incised the skin.All of th rats were examined after eight weeks by electronmicroscope.[Result]There was no special ultrapathological characterization after operation in the control group,while in experimented group most chonduocyte-like cells were degenerated or necrotic and their number decreased markedly,collagenous fibrils appeared various kinds of degeneration including fusion,twist and calcification,and there were gaps between the collagen bundles.[Conclusion]Observing the change in the rat model study of experimental lumbar intervertebral disc degeneration by ultrapathology,it can offer the experimental data studying tile degeneration of lumbar intervertebral disc.
