Expression of P53 protein in oral tumor tissue in smoking and nonsmoking subjects
- VernacularTitle:吸烟和非吸烟者口腔良恶性肿瘤组织中P53蛋白的表达
- Author:
Can XIAO
;
Jianhua ZHOU
;
Jianhua HUI
- Publication Type:Journal Article
- Keywords:
Smoking;
Oral tumor;
p53 gene
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between smoking and P53 protein expression in oral tumor tissue.Methods:The expression of P53 protein in oral tumor tissue was detected in 22 smoking cases and 32 nonsmoking cases by immunohistochemical SP method. SAS software was used for statistic analysis.Results:The positive expression rate of P53 protein in smokers (90.91%) was higher than that in nonsmokers (46.88%,P0.05). Conclusion:Smoking may stimulate the mutation of p53 gene and play an important role in the carcinogenesis of oral tissues.
