Expression of PCNA in submandibular gland of db/db mutant diabetic mice
- VernacularTitle:PCNA在db/db自发性糖尿病小鼠颌下腺的表达
- Author:
Hongyan LIU
;
Xiaochen SONG
;
Fusheng DONG
- Publication Type:Journal Article
- Keywords:
Single gene heredity;
Diabetes mellitus;
Mice;
Submandibular gland;
Gene
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of PCNA and morphological changes of submandibular gland of db/db mutant diabetic mice. Methods:Fifty C57BL/Ksj-db/+m mice were randomly divided into 2 groups, db/db diabetic group and control group. The morphological changes of submandibular gland and the expression of PCNA were observed by using light microscope (LM) and immunohistochemistry. Results:Submandibular gland atrophy and the significant morphological changes in acini and ducts were observed in db/db diabetic mice. PCNA was expressed in submandibular gland in both diabetic mice and control mice.The percentage of PCNA positive cells was significantly decreased in diabetic mice than that in control(P
