The effect of Zhongjiling tablet on T lymphocyte subgroup of ⅡA type myasthenia gravis patients and the level of IFN-?,IL-4 and TGF-?
- VernacularTitle:重肌灵片对ⅡA型重症肌无力外周血T淋巴细胞亚群及细胞因子IFN-?、IL-4、TGF-?水平的影响
- Author:
Yiling WU
;
Fengquan XU
;
Guoqiang YUAN
;
Cong WEI
;
Zhenghua JIA
- Publication Type:Journal Article
- Keywords:
Zhongjiling tablet;
Myasthenia gravis;
T lymphocyte subgroup;
IFN-?;
IL-4;
TGF-?
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the cellular immunological regulation mechanism of Zhongjiling tablet on the myasthenia gravis(MG) patients.Methods:The myasthenia gravis patients were randomly divided into 2 groups, the curing group and the control group, 30 cases per group. Patients of curing group administered Zhongjiling tablet and prednisone placebo, patients of control group administered prednisone tablet and Zhongjiling tablet placebo. Course of treatment was 12 weeks. The distribution of T lymphocyte subgroup of myasthenia gravis patients was detected by flow cytometry. The content of IFN-?, IL-4 and TGF-? of the patients’ peripheral blood mononuclear in vitro were detected by ELISA kits.Results:After treatment, CD4+T cell percentage and the ratio of CD4+/CD8+ decreased significantly(P0.05). The IFN-? and IL-4 of treating group depressed, compared with that of pre-treatment, significant difference exited(P
