Effect of celecoxib on bladder cancer xenografts in nude mice and apoptosis of tumor cells of the xenografts
- VernacularTitle:塞来昔布对膀胱癌裸鼠皮下移植瘤及移植瘤细胞凋亡的影响
- Author:
Liang REN
;
Shukun HOU
;
Xiaofeng WANG
;
Haiyun YE
;
Kaopeng GUAN
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Cyclooxygenase-2;
Celecoxib;
Apoptosis
- From:
Chinese Journal of Urology
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cyclooxygenase-2(COX-2) inhibitor celecoxib on bladder cancer xenografts in nude mice and apoptosis of tumor cells in the xenografts. Methods Models of bladder cancer xenograft in nude mice was used to observe the effect of celecoxib on the animals and the xenografts.TUNEL was used to assess apoptotic index of tumor cells in the xenografts. Results Celecoxib could effectively inhibit the growth of xenografts(P0.05). Conclusions Celecoxib maybe inhibit the growth of bladder cancer via inducing apoptosis of tumor cells and perhaps will become a choice of chemoprevention and adjuvant therapy of bladder cancer.
