Microarray study on the expression of p53,VEGF,E-cad and CK20 in bladder tumor
- VernacularTitle:微阵列技术研究p53,VEGF,E-cad,CK20蛋白在膀胱癌组织中的表达
- Author:
Xiaohui ZHANG
;
Liming LI
;
Yi LIN
;
Wanming QIANG
;
Mingming WU
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Tissue microarrys
- From:
Chinese Journal of Urology
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of p53,VEGF,E-cad,CK20 and its clinical meanings in bladder transitional cell carcinoma. Methods The specimen microarrays and immunohistochemistry were applied to detect selected cancer-related protein expression in 45 cases of bladder TCC and 8 cases of normal control. Results Abnormal expression of p53,E-cad and CK20 were detected 100.0%,55.6%,55.6% respectively in bladder TCC group,which were expressed normally in control group with significant differences.However,there was no VEGF expression differences between those 2 groups (87.5% v.86.7%).Abnormal expression intensity of p53 and expression rate of E-cad were closely related to the pathological features.CK20 expression was co-related positively with disease staging rather than grading.VEGF played less role in co-relating with pathological features. Conclusions p53,E-cad and CK20 play an important roles in the development of bladder TCC,and VEGF plays less.Microarrays is suggested to detect a large scale of specimen for multiple proteins,it is effective.
