Molecular mechanism of EGF signal pathway on cell cycle in prostate cancer adrogen-independent cell line DU145
- VernacularTitle:EGF信号通路对雄激素非依赖性前列腺癌细胞株DU145细胞周期的影响
- Author:
Haijiao CHEN
;
Hao WANG
;
Li ZHANG
;
Guomin WANG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Signal pathway
- From:
Chinese Journal of Urology
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the molecular mechanism of EGF signal pathway on cell cycle in prostate cancer adrogen-independent cell line DU-145. Methods FAC scan was used to analysis the cell cycle and the proliferation ability was measured by MTT assay.We further detect the expression levels of cell cycle factors by Western blotting. Results Our data showed that EGF can increase the proliferation ability of DU145 cells and that can also increase the cell numbers in S phase (P
