Inhibition of bladder activity by 5-HT1 subtype-selective serotonin receptor agonists in cats with chronic spinal cord injury
- VernacularTitle:5-羟色胺受体激动剂对脊髓损伤猫排尿功能的影响
- Author:
Baojun GU
;
Jiemin SI
;
Yuemin XUE
- Publication Type:Journal Article
- Keywords:
Cat;
Spinal cord injury;
Micturition;
Serotonin receptor
- From:
Chinese Journal of Urology
2006;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of bladder activity by 5-hydroxytryptamine serotonin receptor agonists with chronic spinal cord injury(SCI). Methods Intact cats and SCI cats were catheterized through the bladder dome for saline-filling cystometry.Dose-response curves for i.v.8-OH-DPAT and GR-46611 were followed in three cases each by WAY-100635.Threshold volume,capacity,residual volume,micturition volume,and arterial pressure were measured. Results Intact cats showed few significant changes in cystometric variable.SCI cats responded to both 8-OH-DPAT and GR-46611 with dose-dependent increases in threshold volume,capacity,and residual volume.Effects of 8-OH-DPAT but not GR-46611 were largely reversed by WAY-100635. Conclusions Both 5-HT_ 1A and 5-HT_ 1B/1D agonists may offer a promising means of reducing bladder hyperactivity and increasing bldder capacity in patients with chronic SCI.
