Three-dimensional conformal hypofractionated radiotherapy for non-small-cell lung cancer
- VernacularTitle:大分割三维适形放疗在非小细胞肺癌治疗中的应用
- Author:
Songxi XIE
;
Weixiong LI
;
Yingru LIN
;
Wenchang ZOU
- Publication Type:Journal Article
- Keywords:
non-small-cell lung cancer;
conformal hypofractionated radiation therapy;
dose-volume histogram
- From:
China Oncology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:The local tumor control rate of non-small-cell lung cancer treated with conventionally fractionated radiotherapy is low.Hypofractionated radiotherapy performed by conformal irradiation techniques can improne the local control rate.But further studies for appropriate fraction dose and toxicity for hypofractionation should be done.The purpose of this study was to prospectively evaluate the safety and efficacy of three-dimensional conformal hypofractionated radiotherapy for non-small-cell lung cancer(NSCLC).Methods:According to the dose-volume histogram(DVH) V_(20), patients were divided into three groups:① V_(20)≤20%,②20%30%,grade Ⅲ RP was observes in 2 of 5 patients and grade Ⅳ RP in 1 patient who died of lung function failure.No grade≥Ⅲ radiation esophagitis was observed.25 patients were evaluated with 8 complete responses,13 partial responses,3 stable diseases and 1 progressive disease.Conclusions:For three-dimensional conformal hypofractionated radiotherapy V_(20) level should be controlled below 30%,the treatment plan with V_(20)≥30% should be changed to palliative treatment.More studies are needed to confirm its efficacy.
