Advanced understanding in the effect of hypoxia on the expression of matrix metalloproteinase in the promotion of tumor-metastasis
- VernacularTitle:乏氧对基质金属蛋白酶促肿瘤转移的影响研究进展
- Author:
Tao XIE
;
Xianglin YUAN
- Publication Type:Journal Article
- Keywords:
hypoxia;
hypoxia inducible factor-1;
matrix metalloproteinases;
extracellular matrix;
metastasis
- From:
China Oncology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is very common in solid tumor.It results in a series of changes of biological behavior in tumor cells.Hypoxia could facilitate malignant cells metastasis,in which the hypoxia inducible factor-1 plays an important role.The hypothesis for the tumor cells to metastasis is the degradation of the extracellular matrix(ECM).The ECM can be degraded by the matrix metalloproteinase,which is a critical factor in the process of tumor-metastasis.So far,it is not clear whether hypoxia have a role in the regulation of MMPs in tumor.So this review summarize the advanced knowledge on the influence of HIF-1 and MMPs in tumor-metastasis and the interaction between two genes.
