The relationship between immunoregulatory cytokines and intrahepatic metastasis and recurrence in primary hepatocellular carcinoma
- VernacularTitle:原发性肝癌患者细胞因子水平的变化与转移和复发的关系
- Author:
Mujian TENG
;
Minghai WANG
- Publication Type:Journal Article
- Keywords:
Liver neoplasms?Interleukin-1?Interleukin-4?Interferon typeⅡ?Neoplasm metastasis?Neoplasm recurrence,local
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of immunoregulatory cytokines including interleukin-4(IL-4,Th2)、 interferon-?(IFN-?,Th1)、interleukin-betal (IL-1?) in the tissues of hepatocellular carcinoma(HCC),and to investigate the relationship between the changes of immunoregulatory cytokines in patients with hepatocellular carcinoma and intrahepatic metastasis and recurrence.Methods:The immunoregulatory cytokines:IFN-?(Th1)、IL-4(Th2)、IL-1? were analyzed by RT-PCR.Results:34 cases with HCC were compared with the ones with liver cirrhosis,the expression rates and density of IFN-?(Th1) in the tissues of hepatocellular carcinoma were much lower than that in the liver cirrhosis,they are 0.92?0.36(18/34,53.9%) and 1.63?0.64(12/15,80.0%),respectively.There is significant difference between them (P
