Effect of triglitazone on the secretion of vascular active factors from endothelial cells stimulated by AngⅡ
- VernacularTitle:Triglitazone对AngⅡ刺激血管内皮细胞分泌血管活性因子的影响
- Author:
Yongqin LI
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-activated receptor ?(PPAR?);
hypertension;
vascular endothelial cell;
angiotensinⅡ;
vascular active factor;
triglitazone
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To investigate the effect of PPAR ? ligand triglitazone on the secretion of ET-1and NO from endothelial cells stimulated by AngⅡ.Methods The cultured human umbilical vein endothelial cells(HUVECs) were treated with AngⅡand triglitazone.Chemiluminescence analysis was used to measure the concentration of NO,and radioimmunoassay method was used to detect the production of ET-1.Results The HUVECs were treated with 10?mol/L and 50?mol/L triglitazone.The concentration of ET-1 in cell culture supernatants decreased without statistical significance.The concentration of NO increased significantly compared with that of the control(P
